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PML nuclear bodies contribute to the basal expression of the mTOR inhibitor DDIT4

The promyelocytic leukemia (PML) protein is an essential component of PML nuclear bodies (PML NBs) frequently lost in cancer. PML NBs coordinate chromosomal regions via modification of nuclear proteins that in turn may regulate genes in the vicinity of these bodies. However, few PML NB-associated ge...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Sci Rep
Hauptverfasser: Salsman, Jayme, Stathakis, Alex, Parker, Ellen, Chung, Dudley, Anthes, Livia E., Koskowich, Kara L., Lahsaee, Sara, Gaston, Daniel, Kukurba, Kimberly R., Smith, Kevin S., Chute, Ian C., Léger, Daniel, Frost, Laura D., Montgomery, Stephen B., Lewis, Stephen M., Eskiw, Christopher, Dellaire, Graham
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5362932/
https://ncbi.nlm.nih.gov/pubmed/28332630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep45038
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