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Differential regulation of the melanoma proteome by eIF4A1 and eIF4E

Small molecules and antisense oligonucleotides that inhibit the translation initiation factors eIF4A1 and eIF4E have been explored as broad-based therapeutic agents for cancer treatment, based on the frequent upregulation of these two subunits of the eIF4F cap-binding complex in many cancer cells. H...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Joyce, Cailin E., Yanez, Adrienne G., Mori, Akihiro, Yoda, Akinori, Carroll, Johanna S., Novina, Carl D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5362820/
https://ncbi.nlm.nih.gov/pubmed/27879264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-1298
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