Regulation of eIF2α by RNF4 promotes melanoma tumorigenesis and therapy resistance

Among the hallmarks of melanoma, are impaired proteostasis and the rapid development of resistance to targeted therapy, that represent a major clinical challenge. However, the molecular machinery that links these processes is unknown. Here we describe that by stabilizing key melanoma oncoproteins th...

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Detalhes bibliográficos
Publicado no:J Invest Dermatol
Main Authors: Avitan-Hersh, Emily, Feng, Yongmei, Vaisman, Avital Oknin, Ahmed, Yamen Abu, Zohar, Yaniv, Zhang, Tongwu, Lee, Joo Sang, Lazar, Ikrame, Khalil, Saeed Sheikh, Feiler, Yulia, Kluger, Harriet, Kahana, Chaim, Brown, Kevin, Ruppin, Eytan, Ronai, Ze’ev A., Orian, Amir
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8081033/
https://ncbi.nlm.nih.gov/pubmed/32360601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jid.2020.04.008
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