Loss of maternal chromosome 11 is a signature event in SDHAF2, SDHD, and VHL-related paragangliomas, but less significant in SDHB-related paragangliomas

Germline mutations in the succinate dehydrogenase (SDHA, SDHB, SDHC, SDHD, SDHAF2) or Von Hippel-Lindau (VHL) genes cause hereditary paraganglioma/pheochromocytoma. While SDHB (1p36) and VHL (3p25) are associated with autosomal dominant disease, SDHD (11q23) and SDHAF2 (11q13) show a remarkable pare...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Oncotarget
Autores principales: Hoekstra, Attje S., Hensen, Erik F., Jordanova, Ekaterina S., Korpershoek, Esther, Anouk N.A., van der Horst-Schrivers, Cornelisse, Cees, Corssmit, Eleonora P.M., Hes, Frederik J., Jansen, Jeroen C., Kunst, Henricus P.M., Timmers, Henri J.L.M., Bateman, Adrian, Eccles, Diana, Bovée, Judith V.M.G., Devilee, Peter, Bayley, Jean-Pierre
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5362423/
https://ncbi.nlm.nih.gov/pubmed/28099933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14649
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares