Antivascular and antitumor properties of the tubulin-binding chalcone TUB091

We investigated the microtubule-destabilizing, vascular-targeting, anti-tumor and anti-metastatic activities of a new series of chalcones, whose prototype compound is (E)-3-(3’’-amino-4’’-methoxyphenyl)-1-(5’-methoxy-3’,4’-methylendioxyphenyl)-2-methylprop-2-en-1-one (TUB091). X-ray crystallography...

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Dades bibliogràfiques
Publicat a:Oncotarget
Autors principals: Canela, María-Dolores, Noppen, Sam, Bueno, Oskía, Prota, Andrea E., Bargsten, Katja, Sáez-Calvo, Gonzalo, Jimeno, María-Luisa, Benkheil, Mohammed, Ribatti, Domenico, Velázquez, Sonsoles, Camarasa, María-José, Fernando Díaz, J., Steinmetz, Michel O., Priego, Eva-María, Pérez-Pérez, María-Jesús, Liekens, Sandra
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2016
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5362409/
https://ncbi.nlm.nih.gov/pubmed/27224920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9527
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