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A Structural Investigation into Oct4 Regulation by Orphan Nuclear Receptors, Germ Cell Nuclear Factor (GCNF) and Liver Receptor Homolog-1 (LRH-1)

Oct4 is a transcription factor required for maintaining pluripotency and self-renewal in stem cells. Prior to differentiation, Oct4 must be silenced to allow for the development of the three germ layers in the developing embryo. This fine-tuning is controlled by the nuclear receptors, liver receptor...

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Pubblicato in:J Mol Biol
Autori principali: Weikum, Emily R., Tuntland, Micheal L., Murphy, Michael N., Ortlund, Eric A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5362318/
https://ncbi.nlm.nih.gov/pubmed/27984042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2016.10.025
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