Multivalent small molecule pan-RAS inhibitors

Design of small molecules that disrupt protein-protein interactions, including the interaction of RAS proteins and their effectors, have potential use as chemical probes and therapeutic agents. We describe here the synthesis and testing of potential small molecule pan-RAS ligands, which were designe...

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保存先:
書誌詳細
出版年:Cell
主要な著者: Welsch, Matthew E., Kaplan, Anna, Chambers, Jennifer M., Stokes, Michael E., Bos, Pieter H., Zask, Arie, Zhang, Yan, Sanchez-Martin, Marta, Badgley, Michael A., Huang, Christine S., Tran, Timothy H., Akkiraju, Hemanth, Brown, Lewis M., Nandakumar, Renu, Cremers, Serge, Yang, Wan S., Tong, Liang, Olive, Kenneth P., Ferrando, Adolfo, Stockwell, Brent R.
フォーマット: Artigo
言語:Inglês
出版事項: 2017
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5362268/
https://ncbi.nlm.nih.gov/pubmed/28235199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.02.006
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