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K-Ras(G12D) has an allosteric small molecule binding site
KRAS is the most commonly mutated oncogene in human cancer, with particularly high mutation frequencies in pancreatic cancers, colorectal cancers and lung cancers(1). The high prevalence of KRAS mutations and its essential role in many cancers makes it a potentially attractive drug target; however,...
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| Publicado no: | Biochemistry |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8158984/ https://ncbi.nlm.nih.gov/pubmed/31042025 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b01300 |
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