PTK2-mediated degradation of ATG3 impedes cancer cells susceptible to DNA damage treatment

ATG3 (autophagy-related 3) is an E2-like enzyme essential for autophagy; however, it is unknown whether it has an autophagy-independent function. Here, we report that ATG3 is a relatively stable protein in unstressed cells, but it is degraded in response to DNA-damaging agents such as etoposide or c...

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Detalhes bibliográficos
Publicado no:Autophagy
Main Authors: Ma, Ke, Fu, Wan, Tang, Ming, Zhang, Chaohua, Hou, Tianyun, Li, Ran, Lu, Xiaopeng, Wang, Yanan, Zhou, Jingyi, Li, Xue, Zhang, Luyao, Wang, Lina, Zhao, Ying, Zhu, Wei-Guo
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
Assuntos:
Basic Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5361600/
https://ncbi.nlm.nih.gov/pubmed/28103122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2016.1272742
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