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Inducible T cell kinase regulates the acquisition of cytolytic capacity and degranulation in CD8(+) cytotoxic T lymphocytes()

Patients with mutations in ITK are susceptible to viral infections, particularly Epstein Barr Virus, suggesting that these patients have defective function of CD8(+) cytolytic T lymphocytes (CTLs). Here, we evaluated the effects of ITK-deficiency on cytolysis in murine CTLs deficient in ITK, and bot...

詳細記述

保存先:
書誌詳細
出版年:J Immunol
主要な著者: Kapnick, Senta M., Stinchcombe, Jane C., Griffiths, Gillian M., Schwartzberg, Pamela L.
フォーマット: Artigo
言語:Inglês
出版事項: 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5360469/
https://ncbi.nlm.nih.gov/pubmed/28213500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1601202
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