Developmental Role of Macrophage Cannabinoid-1 Receptor Signaling in Type 2 Diabetes

Islet inflammation promotes β-cell loss and type 2 diabetes (T2D), a process replicated in Zucker Diabetic Fatty (ZDF) rats in which β-cell loss has been linked to cannabinoid-1 receptor (CB(1)R)–induced proinflammatory signaling in macrophages infiltrating pancreatic islets. Here, we analyzed CB(1)...

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Bibliografiska uppgifter
I publikationen:Diabetes
Huvudupphovsmän: Jourdan, Tony, Szanda, Gergő, Cinar, Resat, Godlewski, Grzegorz, Holovac, David J., Park, Joshua K., Nicoloro, Sarah, Shen, Yuefei, Liu, Jie, Rosenberg, Avi Z., Liu, Ziyi, Czech, Michael P., Kunos, George
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Diabetes Association 2017
Ämnen:
Pathophysiology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5360301/
https://ncbi.nlm.nih.gov/pubmed/28082458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db16-1199
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