15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-β-induced suppressor of human gastrointestinal cancers

Marked increased expression of cyclooxygenase 2 (COX-2), a prostaglandin-synthesizing enzyme that is pharmacologically inhibited by nonsteroid anti-inflammatory-type drugs, is a major early oncogenic event in the genesis of human colon neoplasia. We report that, in addition to inducing expression of...

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Главные авторы: Yan, Min, Rerko, Ronald M., Platzer, Petra, Dawson, Dawn, Willis, Joseph, Tong, Min, Lawrence, Earl, Lutterbaugh, James, Lu, Shilong, Willson, James K. V., Luo, Guangbin, Hensold, Jack, Tai, Hsin-Hsiung, Wilson, Keith, Markowitz, Sanford D.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2004
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC536023/
https://ncbi.nlm.nih.gov/pubmed/15574495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0406142101
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