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Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an α-synuclein rat model of Parkinson's disease

Parkinson's disease (PD) is characterized by a progressive loss of midbrain dopamine neurons and the presence of cytoplasmic inclusions called Lewy bodies. Mutations in several genes including α-synuclein and parkin have been linked to familial PD. The loss of parkin's E3-ligase activity l...

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Detalhes bibliográficos
Main Authors: Lo Bianco, Christophe, Schneider, Bernard L., Bauer, Matthias, Sajadi, Ali, Brice, Alexis, Iwatsubo, Takeshi, Aebischer, Patrick
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC536019/
https://ncbi.nlm.nih.gov/pubmed/15576511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0405313101
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