Parkin cooperates with GDNF/RET signaling to prevent dopaminergic neuron degeneration

Parkin and the glial cell line–derived neurotrophic factor (GDNF) receptor RET have both been independently linked to the dopaminergic neuron degeneration that underlies Parkinson’s disease (PD). In the present study, we demonstrate that there is genetic crosstalk between parkin and the receptor tyr...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Meka, Durga Praveen, Müller-Rischart, Anne Kathrin, Nidadavolu, Prakash, Mohammadi, Behnam, Motori, Elisa, Ponna, Srinivas Kumar, Aboutalebi, Helia, Bassal, Mahmoud, Annamneedi, Anil, Finckh, Barbara, Miesbauer, Margit, Rotermund, Natalie, Lohr, Christian, Tatzelt, Jörg, Winklhofer, Konstanze F., Kramer, Edgar R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4611569/
https://ncbi.nlm.nih.gov/pubmed/25822020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI79300
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