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Ret is essential to mediate GDNF's neuroprotective and neuroregenerative effect in a Parkinson disease mouse model

Glial cell line-derived neurotrophic factor (GDNF) is a potent survival and regeneration-promoting factor for dopaminergic neurons in cell and animal models of Parkinson disease (PD). GDNF is currently tested in clinical trials on PD patients with so far inconclusive results. The receptor tyrosine k...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Drinkut, Anja, Tillack, Karsten, Meka, Durga P, Schulz, Jorg B, Kügler, Sebastian, Kramer, Edgar R
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5059866/
https://ncbi.nlm.nih.gov/pubmed/27607574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.263
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