Mechanosignaling activation of TGFβ maintains intervertebral disc homeostasis

Intervertebral disc (IVD) degeneration is the leading cause of disability with no disease-modifying treatment. IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal (NC) cells to maintain IVD homeos...

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Bibliographic Details
Published in:	Bone Res
Main Authors:	Bian, Qin, Ma, Lei, Jain, Amit, Crane, Janet L, Kebaish, Khaled, Wan, Mei, Zhang, Zhengdong, Edward Guo, X, Sponseller, Paul D, Séguin, Cheryle A, Riley, Lee H, Wang, Yongjun, Cao, Xu
Format:	Artigo
Language:	Inglês
Published:	Nature Publishing Group 2017
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC5360159/ https://ncbi.nlm.nih.gov/pubmed/28392965 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/boneres.2017.8
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Mechanosignaling activation of TGFβ maintains intervertebral disc homeostasis

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