Mechanosignaling activation of TGFβ maintains intervertebral disc homeostasis

Intervertebral disc (IVD) degeneration is the leading cause of disability with no disease-modifying treatment. IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal (NC) cells to maintain IVD homeos...

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Pubblicato in:Bone Res
Autori principali: Bian, Qin, Ma, Lei, Jain, Amit, Crane, Janet L, Kebaish, Khaled, Wan, Mei, Zhang, Zhengdong, Edward Guo, X, Sponseller, Paul D, Séguin, Cheryle A, Riley, Lee H, Wang, Yongjun, Cao, Xu
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5360159/
https://ncbi.nlm.nih.gov/pubmed/28392965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/boneres.2017.8
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