Excessive Activation of TGFβ by Spinal Instability Causes Vertebral Endplate Sclerosis

Narrowed intervertebral disc (IVD) space is a characteristic of IVD degeneration. EP sclerosis is associated with IVD, however the pathogenesis of EP hypertrophy is poorly understood. Here, we employed two spine instability mouse models to investigate temporal and spatial EP changes associated with...

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Publicat a:Sci Rep
Autors principals: Bian, Qin, Jain, Amit, Xu, Xin, Kebaish, Khaled, Crane, Janet L., Zhang, Zhendong, Wan, Mei, Ma, Lei, Riley, Lee H., Sponseller, Paul D., Guo, X. Edward, Lu, Willian Weijia, Wang, Yongjun, Cao, Xu
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4891769/
https://ncbi.nlm.nih.gov/pubmed/27256073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27093
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