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Excessive Activation of TGFβ by Spinal Instability Causes Vertebral Endplate Sclerosis

Narrowed intervertebral disc (IVD) space is a characteristic of IVD degeneration. EP sclerosis is associated with IVD, however the pathogenesis of EP hypertrophy is poorly understood. Here, we employed two spine instability mouse models to investigate temporal and spatial EP changes associated with...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Bian, Qin, Jain, Amit, Xu, Xin, Kebaish, Khaled, Crane, Janet L., Zhang, Zhendong, Wan, Mei, Ma, Lei, Riley, Lee H., Sponseller, Paul D., Guo, X. Edward, Lu, Willian Weijia, Wang, Yongjun, Cao, Xu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4891769/
https://ncbi.nlm.nih.gov/pubmed/27256073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27093
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