Early Secretory Antigenic Target-6 Drives Matrix Metalloproteinase-10 Gene Expression and Secretion in Tuberculosis

Tuberculosis (TB) causes disease worldwide, and multidrug resistance is an increasing problem. Matrix metalloproteinases (MMPs), particularly the collagenase MMP-1, cause lung extracellular matrix destruction, which drives disease transmission and morbidity. The role in such tissue damage of the str...

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Bibliographic Details
Published in:Am J Respir Cell Mol Biol
Main Authors: Brilha, Sara, Sathyamoorthy, Tarangini, Stuttaford, Laura H., Walker, Naomi F., Wilkinson, Robert J., Singh, Shivani, Moores, Rachel C., Elkington, Paul T., Friedland, Jon S.
Format: Artigo
Language:Inglês
Published: American Thoracic Society 2017
Subjects:
Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5359650/
https://ncbi.nlm.nih.gov/pubmed/27654284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2016-0162OC
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