Targeted disruption of TC-PTP in the proliferative compartment augments STAT3 and AKT signaling and skin tumor development

Tyrosine phosphorylation is a vital mechanism that contributes to skin carcinogenesis. It is regulated by the counter-activities of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs). Here, we report the critical role of T-cell protein tyrosine phosphatase (TC-PTP), encoded by...

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Publicado no:Sci Rep
Main Authors: Lee, Hyunseung, Kim, Mihwa, Baek, Minwoo, Morales, Liza D., Jang, Ik-Soon, Slaga, Thomas J., DiGiovanni, John, Kim, Dae Joon
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5359614/
https://ncbi.nlm.nih.gov/pubmed/28322331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep45077
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