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Protein Tyrosine Phosphatases, TC-PTP, SHP1, and SHP2, Cooperate in Rapid Dephosphorylation of Stat3 in Keratinocytes Following UVB Irradiation

Stat3 is initially dephosphorylated in murine keratinocytes in response to UVB irradiation. Treatment with Na(3)VO(4) desensitized keratinocytes to UVB-induced apoptosis with the recovery of phosphorylated Stat3 protein levels, implying that a protein tyrosine phosphatase (PTP) is involved in this m...

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Hlavní autoři: Kim, Dae Joon, Tremblay, Michel L., DiGiovanni, John
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2858656/
https://ncbi.nlm.nih.gov/pubmed/20421975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010290
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