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Smurf2 up-regulation activates telomere-dependent senescence

Progressive telomere shortening activates replicative senescence, which prevents somatic cells from being propagated indefinitely in culture. The limitation of proliferative capacity imposed by replicative senescence is thought to contribute to both organismal aging and the prevention of tumor devel...

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Detalhes bibliográficos
Main Authors: Zhang, Hong, Cohen, Stanley N.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC535914/
https://ncbi.nlm.nih.gov/pubmed/15574587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1253004
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