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Smurf2 up-regulation activates telomere-dependent senescence
Progressive telomere shortening activates replicative senescence, which prevents somatic cells from being propagated indefinitely in culture. The limitation of proliferative capacity imposed by replicative senescence is thought to contribute to both organismal aging and the prevention of tumor devel...
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| Главные авторы: | , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Cold Spring Harbor Laboratory Press
2004
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC535914/ https://ncbi.nlm.nih.gov/pubmed/15574587 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1253004 |
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