Macrocyclized Extended Peptides: Inhibiting the Substrate-Recognition Domain of Tankyrase

[Image: see text] We report a double-click macrocyclization approach for the design of constrained peptide inhibitors having non-helical or extended conformations. Our targets are the tankyrase proteins (TNKS), poly(ADP-ribose) polymerases (PARP) that regulate Wnt signaling by targeting Axin for deg...

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Publicado en:J Am Chem Soc
Autores principales: Xu, Wenshu, Lau, Yu Heng, Fischer, Gerhard, Tan, Yaw Sing, Chattopadhyay, Anasuya, de la Roche, Marc, Hyvönen, Marko, Verma, Chandra, Spring, David R., Itzhaki, Laura S.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2017
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5358875/
https://ncbi.nlm.nih.gov/pubmed/28084734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b10234
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