Double Strain-Promoted Macrocyclization for the Rapid Selection of Cell-Active Stapled Peptides

Peptide stapling is a method for designing macrocyclic alpha-helical inhibitors of protein–protein interactions. However, obtaining a cell-active inhibitor can require significant optimization. We report a novel stapling technique based on a double strain-promoted azide–alkyne reaction, and exploit...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Lau, Yu Heng, Wu, Yuteng, Rossmann, Maxim, Tan, Ban Xiong, de Andrade, Peterson, Tan, Yaw Sing, Verma, Chandra, McKenzie, Grahame J., Venkitaraman, Ashok R., Hyvönen, Marko, Spring, David R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5868729/
https://ncbi.nlm.nih.gov/pubmed/26768531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201508416
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