PP06. HYPOMETHYLATION OF HEXOKINASE 2 IS A FREQUENT EVENT IN GLIOBLASTOMA MULTIFORME

HK2 is highly expressed in several cancers including colon and breast and its role as the rate-limiting step of glycolysis may potentially contribute to tumour growth. Overexpression of HK2 has also been associated with drug resistant phenotypes. Inhibition of HK2 has increased the effectiveness of...

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Published in:Neuro Oncol
Main Authors: Blakeway, Mr Daniel, Karakoula, Dr Katherine, Morris, Dr Mark, Eagles, Mr Lawrence, Rowther, Dr Farjana Begam, Singh, Dr Anushree, Ashton, Mrs Kate, Dawson, Prof Tim, Darling, Prof John, Warr, Prof Tracy
Format: Artigo
Language:Inglês
Published: Oxford University Press 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5358573/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/now293.005
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