Intranasal siRNA administration reveals IGF2 deficiency contributes to impaired cognition in Fragile X syndrome mice

Molecular mechanisms underlying learning and memory remain imprecisely understood, and restorative interventions are lacking. We report that intranasal administration of siRNAs can be used to identify targets important in cognitive processes and to improve genetically impaired learning and memory. I...

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Vydáno v:JCI Insight
Hlavní autoři: Pardo, Marta, Cheng, Yuyan, Velmeshev, Dmitry, Magistri, Marco, Eldar-Finkelman, Hagit, Martinez, Ana, Faghihi, Mohammad A., Jope, Richard S., Beurel, Eleonore
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2017
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5358485/
https://ncbi.nlm.nih.gov/pubmed/28352664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.91782
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