Intranasal siRNA administration reveals IGF2 deficiency contributes to impaired cognition in Fragile X syndrome mice

Molecular mechanisms underlying learning and memory remain imprecisely understood, and restorative interventions are lacking. We report that intranasal administration of siRNAs can be used to identify targets important in cognitive processes and to improve genetically impaired learning and memory. I...

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:JCI Insight
Päätekijät: Pardo, Marta, Cheng, Yuyan, Velmeshev, Dmitry, Magistri, Marco, Eldar-Finkelman, Hagit, Martinez, Ana, Faghihi, Mohammad A., Jope, Richard S., Beurel, Eleonore
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Clinical Investigation 2017
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5358485/
https://ncbi.nlm.nih.gov/pubmed/28352664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.91782
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