SM protein Munc18-2 facilitates transition of Syntaxin 11-mediated lipid mixing to complete fusion for T-lymphocyte cytotoxicity

The atypical lipid-anchored Syntaxin 11 (STX11) and its binding partner, the Sec/Munc (SM) protein Munc18-2, facilitate cytolytic granule release by cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. Patients carrying mutations in these genes develop familial hemophagocytic lymphohistiocy...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Spessott, Waldo A., Sanmillan, Maria L., McCormick, Margaret E., Kulkarni, Vineet V., Giraudo, Claudio G.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2017
Teme:
PNAS Plus
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5358394/
https://ncbi.nlm.nih.gov/pubmed/28265073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1617981114
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki