Munc18‐2 is required for Syntaxin 11 Localization on the Plasma Membrane in Cytotoxic T‐Lymphocytes

Cytotoxic T‐lymphocytes (CTL) kill their targets by cytolytic granule secretion at the immunological synapse. The Sec/Munc protein, Munc18‐2, and its binding partner Syntaxin 11 (STX11) are both required for granule secretion, with mutations in either leading to the primary immunodeficiency, Familia...

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Bibliographic Details
Published in:Traffic
Main Authors: Dieckmann, Nele M.G., Hackmann, Yvonne, Aricò, Maurizio, Griffiths, Gillian M.
Format: Artigo
Language:Inglês
Published: John Wiley & Sons A/S 2015
Subjects:
Traffic Interchange
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4791091/
https://ncbi.nlm.nih.gov/pubmed/26771955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/tra.12337
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