Sirtuins and Their Roles in Brain Aging and Neurodegenerative Disorders

Sirtuins (SIRT1–SIRT7) are unique histone deacetylases (HDACs) whose activity depends on NAD(+) levels and thus on the cellular metabolic status. SIRTs regulate energy metabolism and mitochondrial function. They orchestrate the stress response and damage repair. Through these functions sirtuins modu...

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Bibliografiske detaljer
Udgivet i:Neurochem Res
Main Authors: Jęśko, Henryk, Wencel, Przemysław, Strosznajder, Robert P., Strosznajder, Joanna B.
Format: Artigo
Sprog:Inglês
Udgivet: Springer US 2016
Fag:
Original Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5357501/
https://ncbi.nlm.nih.gov/pubmed/27882448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11064-016-2110-y
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