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Early and Late Pathomechanisms in Alzheimer’s Disease: From Zinc to Amyloid-β Neurotoxicity

There are several systemic and intracerebral pathologic conditions, which limit provision and utilization of energy precursor metabolites in neuronal cells. Energy deficits cause excessive depolarization of neuronal cells triggering glutamate-zinc evoked excitotoxic cascade. The intracellular zinc e...

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Detalhes bibliográficos
Publicado no:Neurochem Res
Main Authors: Szutowicz, Andrzej, Bielarczyk, Hanna, Zyśk, Marlena, Dyś, Aleksandra, Ronowska, Anna, Gul-Hinc, Sylwia, Klimaszewska-Łata, Joanna
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5357490/
https://ncbi.nlm.nih.gov/pubmed/28039593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11064-016-2154-z
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