Structural analysis and biological activities of BXL0124, a gemini analog of vitamin D

Gemini analogs of calcitriol, characterized by the extension of the C21-methyl group of calcitriol with a second chain, act as agonists of the vitamin D receptor (VDR). This second side chain of gemini is accommodated in a new cavity inside the VDR created by the structural rearrangement of the prot...

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Bibliographic Details
Published in:J Steroid Biochem Mol Biol
Main Authors: Belorusova, Anna Y., Suh, Nanjoo, Lee, Hong Jin, So, Jae Young, Maehr, Hubert, Rochel, Natacha
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5357203/
https://ncbi.nlm.nih.gov/pubmed/27650654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsbmb.2016.09.015
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