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Extensive phosphorylation of Smoothened in Hedgehog pathway activation

The transmembrane protein Smoothened (Smo) is activated in response to the extracellular protein signal, Hedgehog (Hh), and transmits this state of pathway activity into the cell. Previous studies in Drosophila have correlated pathway activation with Smo accumulation and increased phosphorylation. U...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Zhang, Chi, Williams, Elizabeth H., Guo, Yurong, Lum, Lawrence, Beachy, Philip A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2004
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Online Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC535705/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15598741/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0408093101
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