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Extensive phosphorylation of Smoothened in Hedgehog pathway activation

The transmembrane protein Smoothened (Smo) is activated in response to the extracellular protein signal, Hedgehog (Hh), and transmits this state of pathway activity into the cell. Previous studies in Drosophila have correlated pathway activation with Smo accumulation and increased phosphorylation. U...

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Autori principali: Zhang, Chi, Williams, Elizabeth H., Guo, Yurong, Lum, Lawrence, Beachy, Philip A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2004
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC535705/
https://ncbi.nlm.nih.gov/pubmed/15598741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0408093101
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