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Extensive phosphorylation of Smoothened in Hedgehog pathway activation

The transmembrane protein Smoothened (Smo) is activated in response to the extracellular protein signal, Hedgehog (Hh), and transmits this state of pathway activity into the cell. Previous studies in Drosophila have correlated pathway activation with Smo accumulation and increased phosphorylation. U...

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Bibliografski detalji
Izdano u:Proc Natl Acad Sci U S A
Glavni autori: Zhang, Chi, Williams, Elizabeth H., Guo, Yurong, Lum, Lawrence, Beachy, Philip A.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2004
Teme:
Online pristup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC535705/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15598741/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0408093101
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