Inhibition of androgen receptor by decoy molecules delays progression to castration-recurrent prostate cancer

Androgen receptor (AR) is a member of the steroid receptor family and a therapeutic target for all stages of prostate cancer. AR is activated by ligand binding within its C-terminus ligand-binding domain (LBD). Here we show that overexpression of the AR NTD to generate decoy molecules inhibited both...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Myung, Jae-Kyung, Wang, Gang, Chiu, Helen H. L., Wang, Jun, Mawji, Nasrin R., Sadar, Marianne D.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5357013/
https://ncbi.nlm.nih.gov/pubmed/28306720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0174134
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