Targeting androgen receptor activation function-1 with EPI to overcome resistance mechanisms in castration-resistant prostate cancer

PURPOSE: Persistent androgen receptor (AR) transcriptional activity is clinically evident in castration-resistant prostate cancer (CRPC). Therefore, AR remains as a viable therapeutic target for CRPC. All current hormonal therapies target the C-terminus ligand-binding domain (LBD) of AR. By using EP...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Yang, Yu Chi, Banuelos, C Adriana, Mawji, Nasrin R., Wang, Jun, Kato, Minoru, Haile, Simon, McEwan, Iain J., Plymate, Stephen, Sadar, Marianne D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5010454/
https://ncbi.nlm.nih.gov/pubmed/27140928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-2901
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