Refractory testicular germ cell tumors are highly sensitive to the second generation DNA methylation inhibitor guadecitabine

Testicular germ cell tumors (TGCTs) are the most common cancers of young males. A substantial portion of TGCT patients are refractory to cisplatin. There are no effective therapies for these patients, many of whom die from progressive disease. Embryonal carcinoma (EC) are the stem cells of TGCTs. In...

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Detalhes bibliográficos
Publicado no:Oncotarget
Principais autores: Albany, Costantine, Hever-Jardine, Mary P., von Herrmann, Katherine M., Yim, Christina Y., Tam, Janice, Warzecha, Joshua M., Shin, Leah, Bock, Sarah E., Curran, Brian S., Chaudhry, Aneeq S., Kim, Fred, Sandusky, George E., Taverna, Pietro, Freemantle, Sarah J., Christensen, Brock C., Einhorn, Lawrence H., Spinella, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5356854/
https://ncbi.nlm.nih.gov/pubmed/27936464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13811
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