A phase 1 study of combined guadecitabine and cisplatin in platinum refractory germ cell cancer

PURPOSE: Germ cell tumors (GCTs) are cured with therapy based on cisplatin, although a clinically significant number of patients are refractory and die of progressive disease. Based on preclinical studies indicating that refractory testicular GCTs are hypersensitive to hypomethylating agents (HMAs),...

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Detalhes bibliográficos
Publicado no:Cancer Med
Main Authors: Albany, Costantine, Fazal, Zeeshan, Singh, Ratnakar, Bikorimana, Emmanuel, Adra, Nabil, Hanna, Nasser H., Einhorn, Lawrence H., Perkins, Susan M., Sandusky, George E., Christensen, Brock C., Keer, Harold, Fang, Fang, Nephew, Kenneth P., Spinella, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Clinical Cancer Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7826483/
https://ncbi.nlm.nih.gov/pubmed/33135391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.3583
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