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A phase 1 study of combined guadecitabine and cisplatin in platinum refractory germ cell cancer
PURPOSE: Germ cell tumors (GCTs) are cured with therapy based on cisplatin, although a clinically significant number of patients are refractory and die of progressive disease. Based on preclinical studies indicating that refractory testicular GCTs are hypersensitive to hypomethylating agents (HMAs),...
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| Published in: | Cancer Med |
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| Main Authors: | , , , , , , , , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
John Wiley and Sons Inc.
2020
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7826483/ https://ncbi.nlm.nih.gov/pubmed/33135391 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.3583 |
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