MED12 mutations in breast phyllodes tumors: evidence of temporal tumoral heterogeneity and identification of associated critical signaling pathways

Exome sequencing has recently identified highly recurrent MED12 somatic mutations in fibroadenomas (FAs) and phyllodes tumors (PTs). In the present study, based on a large series, we confirmed the presence of MED12 exon 1 and 2 mutations in 49% (41/83) of PTs, 70% (7/10) of FAs and 9.1% (1/11) of fi...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Oncotarget
Hlavní autoři: Laé, Marick, Gardrat, Sophie, Rondeau, Sophie, Richardot, Camille, Caly, Martial, Chemlali, Walid, Vacher, Sophie, Couturier, Jérôme, Mariani, Odette, Terrier, Philippe, Bièche, Ivan
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2016
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5356671/
https://ncbi.nlm.nih.gov/pubmed/27806318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12991
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky