MED12 mutations in breast phyllodes tumors: evidence of temporal tumoral heterogeneity and identification of associated critical signaling pathways

Exome sequencing has recently identified highly recurrent MED12 somatic mutations in fibroadenomas (FAs) and phyllodes tumors (PTs). In the present study, based on a large series, we confirmed the presence of MED12 exon 1 and 2 mutations in 49% (41/83) of PTs, 70% (7/10) of FAs and 9.1% (1/11) of fi...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Laé, Marick, Gardrat, Sophie, Rondeau, Sophie, Richardot, Camille, Caly, Martial, Chemlali, Walid, Vacher, Sophie, Couturier, Jérôme, Mariani, Odette, Terrier, Philippe, Bièche, Ivan
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5356671/
https://ncbi.nlm.nih.gov/pubmed/27806318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12991
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