Ral A, via activating the mitotic checkpoint, sensitizes cells lacking a functional Nf1 to apoptosis in the absence of protein kinase C

Nf1 mutations or deletions are suggested to underlie the tumor predisposition of NF1 (neurofibromatosis type 1) and few treatments are available for treating NF1 patients with advanced malignant tumors. Aberrant activation of Ras in Nf1-deficient conditions is responsible for the promotion of tumori...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Oncotarget
Prif Awduron: Ganapathy, Suthakar, Fagman, Johan B, Shen, Ling, Yu, Tianqi, Zhou, Xiaodong, Dai, Wei, Makriyannis, Alexandros, Chen, Changyan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Impact Journals LLC 2016
Pynciau:
Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5356664/
https://ncbi.nlm.nih.gov/pubmed/27741517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12607
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