Ral A, via activating the mitotic checkpoint, sensitizes cells lacking a functional Nf1 to apoptosis in the absence of protein kinase C

Nf1 mutations or deletions are suggested to underlie the tumor predisposition of NF1 (neurofibromatosis type 1) and few treatments are available for treating NF1 patients with advanced malignant tumors. Aberrant activation of Ras in Nf1-deficient conditions is responsible for the promotion of tumori...

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Foilsithe in:Oncotarget
Main Authors: Ganapathy, Suthakar, Fagman, Johan B, Shen, Ling, Yu, Tianqi, Zhou, Xiaodong, Dai, Wei, Makriyannis, Alexandros, Chen, Changyan
Formáid: Artigo
Teanga:Inglês
Foilsithe: Impact Journals LLC 2016
Ábhair:
Research Paper
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5356664/
https://ncbi.nlm.nih.gov/pubmed/27741517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.12607
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