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Induction of mitotic catastrophe by PKC inhibition in Nf1-deficient cells
Mutations of tumor suppressor Nf1 gene deregulate Ras-mediated signaling, which confers the predisposition for developing benign or malignant tumors. Inhibition of protein kinase C (PKC) was shown to be in synergy with aberrant Ras for the induction of apoptosis in various types of cancer cells. How...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4128879/ https://ncbi.nlm.nih.gov/pubmed/25483185 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.29297 |
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