Induction of mitotic catastrophe by PKC inhibition in Nf1-deficient cells

Mutations of tumor suppressor Nf1 gene deregulate Ras-mediated signaling, which confers the predisposition for developing benign or malignant tumors. Inhibition of protein kinase C (PKC) was shown to be in synergy with aberrant Ras for the induction of apoptosis in various types of cancer cells. How...

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Huvudupphovsmän: Zhou, Xiaodong, Kim, Sung-Hoon, Shen, Ling, Lee, Hyo-Jung, Chen, Changyan
Materialtyp: Artigo
Språk:Inglês
Publicerad: Landes Bioscience 2014
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4128879/
https://ncbi.nlm.nih.gov/pubmed/25483185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.29297
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