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Diversity-oriented solid-phase synthesis and biological evaluation of oligonucleotide hairpins as HIV-1 RT RNase H inhibitors
The inhibitory potencies of several hairpins comprising DNA, RNA and 2′,5′-linked RNA segments were assessed against the RNase H activity of the human immunodeficiency virus reverse transcriptase (HIV-1 RT), an indispensable enzyme for HIV genomic replication. The hairpin library was constructed via...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC535663/ https://ncbi.nlm.nih.gov/pubmed/15570067 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh948 |
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