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Large-Scale Photolithographic Synthesis of Chimeric DNA/RNA Hairpin Microarrays To Explore Sequence Specificity Landscapes of RNase HII Cleavage

[Image: see text] Ribonuclease HII (RNase HII) is an essential endoribonuclease that binds to double-stranded DNA with RNA nucleotide incorporations and cleaves 5′ of the ribonucleotide at RNA–DNA junctions. Thought to be present in all domains of life, RNase HII protects genomic integrity by initia...

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Detalles Bibliográficos
Publicado en:Biochemistry
Main Authors: Lietard, Jory, Damha, Masad J., Somoza, Mark M.
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2019
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6838787/
https://ncbi.nlm.nih.gov/pubmed/31631649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b00806
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