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Large-Scale Photolithographic Synthesis of Chimeric DNA/RNA Hairpin Microarrays To Explore Sequence Specificity Landscapes of RNase HII Cleavage

[Image: see text] Ribonuclease HII (RNase HII) is an essential endoribonuclease that binds to double-stranded DNA with RNA nucleotide incorporations and cleaves 5′ of the ribonucleotide at RNA–DNA junctions. Thought to be present in all domains of life, RNase HII protects genomic integrity by initia...

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Veröffentlicht in:Biochemistry
Hauptverfasser: Lietard, Jory, Damha, Masad J., Somoza, Mark M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2019
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6838787/
https://ncbi.nlm.nih.gov/pubmed/31631649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.9b00806
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