Overexpression of Parkinson’s Disease-Associated Mutation LRRK2 G2019S in Mouse Forebrain Induces Behavioral Deficits and α-Synuclein Pathology

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene have been identified as an unambiguous cause of late-onset, autosomal-dominant familial Parkinson’s disease (PD) and LRRK2 mutations are the strongest genetic risk factor for sporadic PD known to date. A number of transgenic mice expressing...

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Détails bibliographiques
Publié dans:eNeuro
Auteurs principaux: Xiong, Yulan, Neifert, Stewart, Karuppagounder, Senthilkumar S., Stankowski, Jeannette N., Lee, Byoung Dae, Grima, Jonathan C., Chen, Guanxing, Ko, Han Seok, Lee, Yunjong, Swing, Debbie, Tessarollo, Lino, Dawson, Ted M., Dawson, Valina L.
Format: Artigo
Langue:Inglês
Publié: Society for Neuroscience 2017
Sujets:
New Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355896/
https://ncbi.nlm.nih.gov/pubmed/28321439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0004-17.2017
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